StockCIK 2022626

Upstream Bio, Inc. (UPB): Insider Trades and Fund Holdings

In the past 12 months, Upstream Bio, Inc. insiders reported 0 open-market purchases worth $0 and 5 sales worth $28K; 0 of the sales were reported as made under a 10b5-1 trading plan.

0Insider buys, 12 months

$0Bought by insiders, 12 months

$28KSold by insiders, 12 months

1Tracked funds holding

Timeline: news and trades

Company filings (8-K), insider trades, notices of planned sales (Form 144) and fund moves in the past year, newest first.

Sep 16, 2026Insider saleCEO Everett Rand Sutherland sold $11,502
Sep 16, 2026Insider saleChief Medical Officer Aaron Deykin sold $4,914
Sep 16, 2026Insider saleCFO Michael Gray sold $4,683
Sep 16, 2026Insider saleChief Business Officer Adam Houghton sold $3,843
Sep 16, 2026Insider saleGeneral Counsel Allison Ambrose sold $2,663
Jun 30, 2026FundRenaissance Technologies added 111% in Q2 2026 (13F filed Aug 13, 2026)

Recent insider trades

Open-market purchases (code P) and sales (code S) from Form 4. Grants, option exercises and gifts are not shown. Latest filing: Sep 17, 2026.

Recent UPB insider trades
Filed	Traded	Insider	Role	Type	Shares	Price ($)	Value	Holding	Filing
Sep 17	Sep 16	Everett Rand SutherlandCEO	CEO	▼ SELL	2,095	5.49	$12K	−3.0%	Form 4 ↗
Sep 17	Sep 16	Aaron DeykinChief Medical Officer	Chief Medical Officer	▼ SELL	895	5.49	$5K	−2.7%	Form 4 ↗
Sep 17	Sep 16	Michael GrayCFO	CFO	▼ SELL	853	5.49	$5K	−3.0%	Form 4 ↗
Sep 17	Sep 16	Adam HoughtonChief Business Officer	Chief Business Officer	▼ SELL	700	5.49	$4K	−3.0%	Form 4 ↗
Sep 17	Sep 16	Allison AmbroseGeneral Counsel	General Counsel	▼ SELL	485	5.49	$3K	−3.0%	Form 4 ↗

Source: SEC Form 4 filings, retrieved Oct 28, 2026. How we read filings

Insiders who traded in the past year

Insider	Role	Bought	Sells	Sold	Latest
Everett Rand Sutherland	CEO	$0	1	$12K	Sep 17, 2026
Aaron Deykin	Chief Medical Officer	$0	1	$5K	Sep 17, 2026
Michael Gray	CFO	$0	1	$5K	Sep 17, 2026
Adam Houghton	Chief Business Officer	$0	1	$4K	Sep 17, 2026
Allison Ambrose	General Counsel	$0	1	$3K	Sep 17, 2026

Tracked funds that report UPB

From each fund's latest 13F. Holdings are as of quarter end and are filed up to 45 days later.

Fund	Quarter	Shares	Value	% of portfolio	Change
Renaissance Technologies	Q2 2026	131,300	$909K	0.00%	▲ +111.4%

Source: SEC Form 13F-HR filings, retrieved Oct 28, 2026. How we read filings

Reading these numbers

Insiders sell for many reasons: taxes, diversification, a house. Purchases with their own money are rarer and are usually read as more informative. A Form 4 is due within two business days of the trade. How to read a Form 4 →