Opaleye Management Inc.: Insider Trades
Every open-market purchase and sale Opaleye Management Inc. reported on Form 4 since Feb 12, 2026, with how the stock moved after each purchase.
Our read on Opaleye Management Inc.'s trades
Of 23 purchases we can measure six months on, 22 were followed by a rise; the average move was +55.9%, and 22 of 23 beat the S&P 500.
13 of their 13 sales were not under a pre-set plan.
They have reported trades in 6 companies: GRCE, ACOG, SLGL, ETON, SNWV and others, usually as a director or officer of each.
Track record of purchases
Of 23 purchases we can measure after 6 months, 22 beat the S&P 500. On average the stock did 42.2 percentage points better than the index.
| After | Purchases measured | Average change | Median | Vs. S&P 500 | Rose |
|---|---|---|---|---|---|
| 1 week | 60 | +4.7% | +3.0% | +5.1% | 42 of 60 |
| 1 month | 60 | +14.5% | +13.9% | +14.0% | 44 of 60 |
| 3 months | 33 | +37.7% | +43.5% | +28.4% | 31 of 33 |
| 6 months | 23 | +55.9% | +60.5% | +42.2% | 22 of 23 |
Change in the stock price from the price paid to the closest weekly price about 1 week, 1 month, 3 months, 6 months and 1 year later, from SEC fails-to-deliver data. "Vs. S&P 500" subtracts the change in the SPY ETF over the same weeks. Dividends are not included, and purchases with a possible stock split in between are skipped. Past results do not predict future ones. How we measure this
All reported trades
| Filed | Ticker | Role | Type | Value | Score | 3 mo. after |
|---|---|---|---|---|---|---|
| Oct 26 | GRCE | 10% owner (ind.) | ▲ BUY | $117K | 15 | |
| Oct 26 | ACOG | 10% owner (ind.) | ▲ BUY | $123K | 15 | |
| Oct 26 | ACOG | 10% owner (ind.) | ▲ BUY | $143K | 15 | |
| Oct 26 | GRCE | 10% owner (ind.) | ▲ BUY | $41K | 10 | |
| Oct 21 | GRCE | 10% owner (ind.) | ▲ BUY | $8K | 7 | |
| Oct 19 | ACOG | 10% owner (ind.) | ▲ BUY | $118K | 15 | |
| Oct 16 | GRCE | 10% owner (ind.) | ▲ BUY | $69K | 10 | |
| Oct 19 | ACOG | 10% owner (ind.) | ▲ BUY | $191K | 15 | |
| Oct 16 | GRCE | 10% owner (ind.) | ▲ BUY | $46K | 10 | |
| Oct 16 | GRCE | 10% owner (ind.) | ▲ BUY | $22K | 7 | |
| Oct 13 | GRCE | 10% owner (ind.) | ▲ BUY | $15K | 7 | |
| Oct 13 | GRCE | 10% owner (ind.) | ▲ BUY | $11K | 16 | |
| Oct 13 | GRCE | 10% owner (ind.) | ▲ BUY | $4K | 16 | |
| Oct 5 | GRCE | 10% owner (ind.) | ▲ BUY | $3K | 16 | |
| Oct 5 | GRCE | 10% owner (ind.) | ▲ BUY | $41K | 19 | |
| Oct 5 | GRCE | 10% owner (ind.) | ▲ BUY | $79K | 19 | |
| Oct 2 | ACOG | 10% owner (ind.) | ▲ BUY | $166K | 15 | |
| Oct 1 | GRCE | 10% owner (ind.) | ▲ BUY | $16K | 16 | |
| Sep 28 | ACOG | 10% owner (ind.) | ▲ BUY | $114K | 15 | |
| Sep 28 | ACOG | 10% owner (ind.) | ▲ BUY | $157K | 15 | |
| Sep 23 | GRCE | 10% owner (ind.) | ▲ BUY | $11K | 19 | |
| Sep 23 | GRCE | 10% owner (ind.) | ▲ BUY | $21K | 19 | |
| Sep 16 | ACOG | 10% owner (ind.) | ▲ BUY | $683K | 28 | |
| Sep 16 | ACOG | 10% owner (ind.) | ▲ BUY | $29K | 19 | |
| Sep 16 | ACOG | 10% owner (ind.) | ▲ BUY | $351K | 24 | |
| Sep 14 | SLGL | 10% owner (ind.) | ▲ BUY | $98K | 17 | |
| Sep 14 | SLGL | 10% owner (ind.) | ▲ BUY | $109K | 22 | |
| Sep 10 | GRCE | 10% owner (ind.) | ▲ BUY | $12K | 19 | |
| Sep 9 | SLGL | 10% owner (ind.) | ▲ BUY | $213K | 22 | |
| Sep 10 | GRCE | 10% owner (ind.) | ▲ BUY | $20K | 19 | |
| Sep 9 | SLGL | 10% owner (ind.) | ▲ BUY | $266K | 22 | |
| Sep 9 | SLGL | 10% owner (ind.) | ▲ BUY | $209K | 18 | |
| Sep 3 | SLGL | 10% owner (ind.) | ▲ BUY | $62K | 13 | |
| Sep 3 | SLGL | 10% owner (ind.) | ▲ BUY | $54K | 13 | |
| Aug 31 | SLGL | 10% owner (ind.) | ▲ BUY | $356K | 18 | |
| Aug 31 | SLGL | 10% owner (ind.) | ▲ BUY | $2.43M | 26 | |
| Aug 19 | GRCE | 10% owner (ind.) | ▲ BUY | $24K | 16 | |
| Aug 14 | SLGL | 10% owner (ind.) | ▲ BUY | $68K | 10 | |
| Aug 4 | ACOG | 10% owner (ind.) | ▲ BUY | $400K | 24 | |
| Aug 4 | ACOG | 10% owner (ind.) | ▲ BUY | $23K | 16 | |
| Jul 28 | ACOG | 10% owner (ind.) | ▲ BUY | $1K | 14 | |
| Jul 24 | ACOG | 10% owner (ind.) | ▲ BUY | $389K | 24 | |
| Jul 24 | ACOG | 10% owner (ind.) | ▲ BUY | $1.18M | 49 | |
| Jul 16 | ETON | 10% owner (ind.) | ▼ SELL | $1.06M | ||
| Jul 15 | SLGL | 10% owner (ind.) | ▲ BUY | $68K | 13 | |
| Jul 15 | SLGL | 10% owner (ind.) | ▲ BUY | $57K | 13 | |
| Jul 10 | SLGL | 10% owner (ind.) | ▲ BUY | $17K | 8 | |
| Jul 10 | SLGL | 10% owner (ind.) | ▲ BUY | $22K | 10 | |
| Jul 7 | ETON | 10% owner (ind.) | ▼ SELL | $1.02M | ||
| Jul 7 | ETON | 10% owner (ind.) | ▼ SELL | $380K | ||
| Jul 7 | ETON | 10% owner (ind.) | ▼ SELL | $3.36M | ||
| Jul 2 | SLGL | 10% owner (ind.) | ▲ BUY | $101K | 18 | −7.1% |
| Jul 2 | SLGL | 10% owner (ind.) | ▲ BUY | $22K | 10 | −7.1% |
| Jun 29 | ACOG | 10% owner (ind.) | ▲ BUY | $975K | 23 | +40.1% |
| Jun 29 | ACOG | 10% owner (ind.) | ▲ BUY | $1K | 5 | +37.9% |
| Jun 15 | ACOG | 10% owner (ind.) | ▲ BUY | $27K | 19 | +49.8% |
| Jun 15 | ACOG | 10% owner (ind.) | ▲ BUY | $2K | 14 | +60.5% |
| Jun 15 | ACOG | 10% owner (ind.) | ▲ BUY | $17K | 16 | +61.2% |
| Jun 11 | ACOG | 10% owner (ind.) | ▲ BUY | $35K | 19 | +59.0% |
| Jun 11 | ACOG | 10% owner (ind.) | ▲ BUY | $149K | 24 | +59.3% |
| Jun 9 | ACOG | 10% owner (ind.) | ▲ BUY | $59K | 19 | +63.3% |
| May 29 | ACOG | 10% owner (ind.) | ▲ BUY | $416K | 24 | +49.8% |
| May 29 | ACOG | 10% owner (ind.) | ▲ BUY | $12K | 16 | +51.6% |
| May 29 | ACOG | 10% owner (ind.) | ▲ BUY | $7K | 14 | +54.3% |
| May 22 | ACOG | 10% owner (ind.) | ▲ BUY | $91K | 19 | +55.1% |
| May 22 | SLGL | 10% owner (ind.) | ▲ BUY | $101K | 15 | +31.4% |
| May 22 | ACOG | 10% owner (ind.) | ▲ BUY | $50K | 19 | +50.1% |
| May 19 | ACOG | 10% owner (ind.) | ▲ BUY | $99K | 19 | +55.3% |
| May 19 | ACOG | 10% owner (ind.) | ▲ BUY | $97K | 19 | +52.6% |
| May 14 | SLGL | 10% owner (ind.) | ▲ BUY | $130K | 15 | +31.6% |
| May 14 | SLGL | 10% owner (ind.) | ▲ BUY | $102K | 15 | +29.4% |
| May 4 | SNWV | 10% owner (ind.) | ▼ SELL | $170K | ||
| May 4 | SNWV | 10% owner (ind.) | ▼ SELL | $404K | ||
| Apr 30 | SNWV | 10% owner (ind.) | ▼ SELL | $420K | ||
| Apr 30 | SNWV | 10% owner (ind.) | ▼ SELL | $855K | ||
| Apr 21 | SNWV | 10% owner (ind.) | ▼ SELL | $4K | ||
| Apr 21 | SNWV | 10% owner (ind.) | ▼ SELL | $333K | ||
| Mar 31 | ACOG | 10% owner (ind.) | ▲ BUY | $9K | 10 | +56.2% |
| Mar 31 | ACOG | 10% owner (ind.) | ▲ BUY | $51K | 17 | +53.4% |
| Mar 26 | ACOG | 10% owner (ind.) | ▲ BUY | $39K | 17 | +47.4% |
| Mar 26 | ACOG | 10% owner (ind.) | ▲ BUY | $47K | 17 | +43.5% |
| Mar 26 | ACOG | 10% owner (ind.) | ▲ BUY | $23K | 14 | +39.4% |
| Mar 24 | SLGL | 10% owner (ind.) | ▲ BUY | $2.86M | 40 | +3.4% |
| Mar 20 | ACOG | 10% owner (ind.) | ▲ BUY | $12K | 14 | +17.1% |
| Mar 20 | ACOG | 10% owner (ind.) | ▲ BUY | $14K | 14 | +16.2% |
| Mar 18 | ACOG | 10% owner (ind.) | ▲ BUY | $8K | 14 | +15.5% |
| Mar 13 | ACOG | 10% owner (ind.) | ▲ BUY | $42K | 13 | +16.2% |
| Mar 13 | ACOG | 10% owner (ind.) | ▲ BUY | $33K | 13 | +14.1% |
| Mar 10 | ACOG | 10% owner (ind.) | ▲ BUY | $13K | 10 | +14.2% |
| Mar 10 | ACOG | 10% owner (ind.) | ▲ BUY | $11K | 7 | |
| Mar 6 | ACOG | 10% owner (ind.) | ▲ BUY | $273K | 33 | |
| Mar 6 | ACOG | 10% owner (ind.) | ▲ BUY | $115K | 15 | |
| Mar 5 | HROW | 10% owner (ind.) | ▼ SELL | $5.49M | ||
| Mar 5 | HROW | 10% owner (ind.) | ▼ SELL | $2.36M | ||
| Mar 4 | ACOG | 10% owner (ind.) | ▲ BUY | $296K | 33 | |
| Mar 4 | ACOG | 10% owner (ind.) | ▲ BUY | $116K | 15 | |
| Mar 3 | HROW | 10% owner (ind.) | ▼ SELL | $271K | ||
| Mar 2 | ACOG | 10% owner (ind.) | ▲ BUY | $22K | 10 | |
| Mar 2 | ACOG | 10% owner (ind.) | ▲ BUY | $4K | 8 | |
| Feb 24 | ACOG | 10% owner (ind.) | ▲ BUY | $340K | 36 | |
| Feb 24 | ACOG | 10% owner (ind.) | ▲ BUY | $589K | 40 | |
| Feb 24 | ACOG | 10% owner (ind.) | ▲ BUY | $75K | 26 | |
| Feb 18 | SLGL | 10% owner (ind.) | ▲ BUY | $18K | 7 | |
| Feb 18 | SLGL | 10% owner (ind.) | ▲ BUY | $6K | 5 | +29.0% |
Names come from the filings. Different people can share a name, so we group trades by the SEC's reporting-owner number (CIK) instead.
Sources
- Form 4: GRCE, purchase of 66,411 shares · filed 2026-10-26
- Form 4: ACOG, purchase of 14,973 shares · filed 2026-10-26
- Form 4: ACOG, purchase of 17,117 shares · filed 2026-10-26
- Form 4: GRCE, purchase of 21,390 shares · filed 2026-10-26
- Form 4: GRCE, purchase of 4,256 shares · filed 2026-10-21
- Form 4: ACOG, purchase of 14,283 shares · filed 2026-10-19
- Form 4: GRCE, purchase of 36,347 shares · filed 2026-10-16
- Form 4: ACOG, purchase of 22,657 shares · filed 2026-10-19
The 8 most recent filings; every trade in the table links to its own Form 4.
About this page
Insider trades reported on SEC Form 4: when the people who run a company buy or sell its shares with their own money.
How to read it
- Form 4
- The form a company insider (officer, director or owner of more than 10%) must file with the SEC within two business days of buying or selling the company's shares.
- Buy (P) and Sell (S)
- Open-market purchases and sales. Gifts, option exercises and automatic tax withholding are left out because they say little about what the insider thinks.
- Value
- Shares times price, as reported on the filing.
- 10b5-1
- A trade made under a plan set up in advance. Planned sales are common and usually say less than an unplanned purchase.
- Late filing
- A Form 4 filed more than two business days after the trade.
- Vs. S&P 500
- How the stock did after the trade minus how the overall market did in the same weeks.
A real example
In January 2016, when bank stocks were falling, JPMorgan Chase CEO Jamie Dimon bought 500,000 JPMorgan shares with his own money, worth about $26 million. His Form 4 made the purchase public within days, and investors read it as a strong sign of confidence.
Explain it like I'm 13
If the coach of a team bets his own allowance that his team will win, that tells you something. A Form 4 is the note a company boss must hand in whenever he buys or sells his own company's shares, so everyone can see it.
Data from public SEC filings and congressional reports. Information, not investment advice. Check every number against the filing linked on the page.